Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Summary: Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, and deregulated global gene expression.In patients with T cell acute Mug lymphoblastic leukemia (T-ALL), we find that acquired monoallelic CTCF-inactivating events drive

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